Nathalie Vergnolle Selected Research

Proteinase-Activated Receptors

5/2021	Increased Mucosal Thrombin is Associated with Crohn's Disease and Causes Inflammatory Damage through Protease-activated Receptors Activation.
7/2018	Protease-activated receptor 1 is implicated in irritable bowel syndrome mediators-induced signaling to thoracic human sensory neurons.
1/2013	Modulation of protease activated receptor 1 influences human metapneumovirus disease severity in a mouse model.
9/2009	Protease-activated receptors as drug targets in inflammation and pain.
3/2009	Triggering of proteinase-activated receptor 4 leads to joint pain and inflammation in mice.
1/2008	Proteinase-activated receptors (PARs) in infection and inflammation in the gut.
10/2007	Proteinase-activated receptor-2 exerts protective and pathogenic cell type-specific effects in Alzheimer's disease.
9/2007	Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia.
9/2007	Proteinase-activated receptor-2 (PAR2): a tumor suppressor in skin carcinogenesis.
2/2006	Proteinase-activated receptor 2 modulates neuroinflammation in experimental autoimmune encephalomyelitis and multiple sclerosis.

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Nathalie Vergnolle Research Topics

Disease

63	Inflammation (Inflammations) 01/2022 - 04/2002
22	Pain (Aches) 01/2021 - 10/2003
17	Colitis 09/2021 - 09/2003
16	Hyperalgesia 12/2018 - 03/2002
12	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 05/2021 - 11/2002
10	Hypersensitivity (Allergy) 01/2019 - 03/2007
9	Neoplasms (Cancer) 01/2022 - 06/2005
9	Visceral Pain 01/2021 - 04/2002
7	Infections 01/2016 - 04/2006
6	Edema (Dropsy) 05/2013 - 09/2007
5	Crohn Disease (Crohn's Disease) 11/2021 - 11/2002
5	Ischemia 11/2017 - 07/2006
4	Abdominal Pain (Pain, Abdominal) 12/2018 - 01/2012
4	Irritable Bowel Syndrome (Syndrome, Irritable Bowel) 12/2018 - 03/2007
3	Ulcerative Colitis 01/2022 - 11/2002
3	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2022 - 03/2010
3	Colorectal Neoplasms (Colorectal Cancer) 12/2020 - 01/2016
3	Neuroinflammatory Diseases 10/2007 - 06/2005
3	Neurogenic Inflammation 09/2007 - 09/2003
2	Interstitial Cystitis (Interstitial Cystitis, Chronic) 01/2021 - 01/2020
2	Cystitis 01/2021 - 05/2013
2	Colonic Neoplasms (Colon Cancer) 12/2020 - 01/2016
2	Neoplasm Metastasis (Metastasis) 01/2019 - 09/2007
2	Celiac Disease (Celiac Sprue) 01/2019 - 05/2014
2	Hemorrhage 01/2018 - 05/2013
2	Experimental Arthritis 01/2017 - 11/2009
2	Arthritis (Polyarthritis) 01/2017 - 04/2005
2	Communicable Diseases (Infectious Diseases) 05/2008 - 01/2008
2	Wounds and Injuries (Trauma) 07/2006 - 09/2003
2	Multiple Sclerosis 02/2006 - 03/2003

Drug/Important Bio-Agent (IBA)

42	Peptide Hydrolases (Proteases)FDA Link 05/2021 - 04/2002
16	Proteinase-Activated ReceptorsIBA 05/2021 - 10/2003
9	PAR-2 ReceptorIBA 12/2017 - 04/2002
9	Peptides (Polypeptides)IBA 04/2009 - 03/2003
7	CytokinesIBA 01/2022 - 06/2005
7	Capsaicin (Zostrix)FDA Link 01/2012 - 04/2003
6	Thrombin FDA Link 11/2021 - 03/2002
6	TrypsinIBA 09/2021 - 11/2002
5	Serine Proteases (Serine Protease)IBA 09/2021 - 06/2005
5	Opioid Analgesics (Opioids)IBA 01/2021 - 06/2006
5	Analgesics (Analgesic Drugs)IBA 01/2021 - 03/2005
5	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 12/2018 - 03/2003
5	Peroxidase (Myeloperoxidase)IBA 04/2013 - 04/2003
4	AcidsIBA 05/2021 - 09/2010
4	AntigensIBA 01/2021 - 02/2012
4	Messenger RNA (mRNA)IBA 01/2019 - 03/2003
4	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 12/2018 - 01/2013
4	Dextran SulfateIBA 01/2018 - 01/2014
4	Small Interfering RNA (siRNA)IBA 08/2015 - 06/2007
4	ElafinIBA 02/2015 - 04/2011
4	NeuropeptidesIBA 04/2013 - 09/2003
4	CarrageenanIBA 11/2009 - 03/2002
4	Calcitonin Gene-Related PeptideIBA 02/2007 - 09/2003
3	Insulin (Novolin)FDA Link 01/2022 - 03/2010
3	VaccinesIBA 01/2021 - 01/2013
3	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2020 - 05/2013
3	PAR-1 ReceptorIBA 07/2018 - 03/2003
3	Tryptases (Tryptase)IBA 01/2017 - 11/2002
3	Phenobarbital (Luminal)FDA Link 02/2016 - 11/2002
3	Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA 02/2015 - 04/2011
3	salicylhydroxamic acid (SHAM)IBA 01/2012 - 06/2006
3	Dextrans (Dextran)FDA Link 04/2011 - 11/2004
3	Calcium Channels (Calcium Channel)IBA 01/2011 - 08/2009
3	Formaldehyde (Formol)FDA Link 11/2009 - 01/2008
3	Proteins (Proteins, Gene)FDA Link 10/2007 - 09/2004
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 12/2006 - 04/2003
2	Pancreatic Elastase (Elastase)IBA 01/2021 - 01/2019
2	Ibuprofen (Motrin)FDA LinkGeneric 01/2020 - 05/2013
2	Focal Adhesion Protein-Tyrosine KinasesIBA 01/2019 - 08/2012
2	Protein Isoforms (Isoforms)IBA 01/2019 - 06/2007
2	Cromolyn Sodium (Cromoglicic Acid)FDA LinkGeneric 01/2019 - 07/2006
2	Biomarkers (Surrogate Marker)IBA 12/2018 - 05/2013
2	LipidsIBA 11/2017 - 01/2013
2	Interleukin-6 (Interleukin 6)IBA 01/2017 - 05/2013
2	InterleukinsIBA 05/2016 - 09/2005
2	Arachidonic Acid (Vitamin F)IBA 01/2016 - 01/2011
2	15-hydroxy-5,8,11,13-eicosatetraenoic acidIBA 01/2016 - 08/2015
2	Formyl Peptide Receptors (Formyl Peptide Receptor)IBA 01/2016 - 07/2013
2	Ion Channels (Ion Channel)IBA 07/2015 - 02/2007
2	Interleukin-10 (Interleukin 10)IBA 02/2015 - 09/2005
2	Biological ProductsIBA 08/2013 - 02/2005
2	EicosanoidsIBA 08/2013 - 01/2013
2	lipoxin A4IBA 07/2013 - 01/2013
2	Protease Inhibitors (Protease Inhibitor)IBA 06/2013 - 04/2011
2	Morphine (MS Contin)FDA LinkGeneric 05/2013 - 01/2012
2	SolutionsIBA 01/2012 - 09/2010
2	Sulfonic AcidsIBA 04/2011 - 11/2004
2	CalciumIBA 01/2011 - 09/2008
2	LigandsIBA 01/2011 - 10/2004
2	sodium sulfate (sodium bisulfate)FDA LinkGeneric 09/2010 - 11/2004
2	Pharmaceutical PreparationsIBA 09/2009 - 11/2004
2	Substance PIBA 02/2007 - 05/2004
2	TRPV Cation ChannelsIBA 09/2006 - 05/2004
2	Protons (Proton)IBA 09/2006 - 05/2004
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2005 - 06/2005

Therapy/Procedure

4	Injections 08/2015 - 04/2002
3	Oral Administration 01/2018 - 10/2012
2	Spinal Injections 08/2015 - 04/2010
2	Intra-Articular Injections 06/2012 - 03/2009
2	Analgesia 02/2012 - 11/2009